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The synthetic cannabinoid 5F-CUMYL-PINACA, sometimes known as SGT-25 and occasionally marketed as C-Liquid for e-cigarettes, is based on the indazole-3-carboxamide molecule. The original patent claimed roughly 4x selectivity for CB1, with an EC50 of 0.1 nM for human CB1 receptors and 0.37 nM for human CB2 receptors. 5F-CUMYL-PINACA functions as a strong agonist for the cannabinoid receptors. Recent assays using various techniques have revealed that 5F-CUMYL-PINACA has an EC50 of 0.43 nM at CB1 and 11.3 nM at CB2, suggesting a slightly higher CB1 selectivity of 26 times, or alternatively 15.1 nM at CB1 and 34.8 nM at CB2 with only 2.3 times selectivity. However, these numbers cannot be directly compared because of the various assay techniques used in each case.

SGT-25 is not currently available for human use and should only be used for research purposes.

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