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Proscaline

Proskaline/Proskaline is a relatively new designer drug with hallucinogenic and psychedelic properties and structural and pharmacodynamic properties similar to drugs such as Mescaline, Isoproskaline, and Escaline. The unusual psychedelic stimulant phenethylamine, which is an analog of mescaline and has similar effects, has structural/pharmacological properties similar to those of its mescaline analogs such as isoproscaline, escaline, and allylescalin. Proskaline has structural, pharmacological, and chemical properties very similar to the psychedelic stimulants often used as designer drugs. [Sources: 1, 5, 10]

Proskaline (4-propoxy-3,5 -DMPEA) is a psychedelic and hallucinogenic drug that is used as an entheogen. Proscaline is a class of compounds known as phenethylamines and is the 4-propanedoxy homologue of mescaline. It is a 4-propyloxy analog of mescaline, which means that it has an additional carbon alkyloxy group, while escaline is a closely related mescamine analog. [Sources: 1, 4, 15]

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Proskaline (or 4-propoxy-35-dMPEA) is a psychedelic and hallucinogenic drug used by some as an entheogen. It is believed that its psychedelic effect stems from its effectiveness as a partial agonist of the 5-HT-2A receptor. Escalin (4-ethoxy homologist) and mescaline (proscaline-4-propoxy homologist) are themselves two to three times stronger than mescaline. [Sources: 3, 5, 13]

The effects of proscaline

The hallucinogenic potency of mescaline is increased by the methylation homologation of the 4-methoxy group, although it is not clear whether structural modifications on the activity of the drug in rodent models have a similar effect. Escalin is twice as effective in mice as mescaline, while prescaling is twice as effective. Subjective effects are similar to those of Mescaline, including open and closed eyes, visual and temporal distortions, improved introspection and conceptual thinking, euphoria, and ego loss. [Sources: 3, 13]

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It has been reported to cause less visual effects, euphoria, and ego loss than mescaline. Mescaline has a lower logP (0.78) than the values for escalin (logP 1.11) and proscaline (logCp 1.70), which is close to the optimum value (Nichols and Dyer 1977; Nichols and Dyer 1977). A synthesis of proscamine was published by David E. Nichols in 1977 and appeared on the online market for research chemicals in the 2010s. [Sources: 3, 13]

What Happens When You Overdose On Proscaline?

The toxicity and long-term health effects of the use of recreational drugs are not reported in a scientific context and the exact toxic dosages are unknown. Proscaline is a 3,5-dimethoxy-4-propyloxyphenethylamine (substituted phenethylamine) with a phenyl ring bound to an amino group of the ethyl chain. [Sources: 13]

Precautions to take while using proscaline

To compare the behavioral effects of mescaline analogs, I used head twitches in mice. Homologation with the 4-alkoxy group had similar effects on efficacy in mice (HTR). In contrast, efficacy was increased by inducing homologations with 4-methoxy groups of mescaline (TMA-1) and TMA-2, but it had little or no effect on behavioral efficacy. [Sources: 3, 12]

Proskaline (4-Propyloxy-3,5-di-Methoxy-Phenethylamine). Proskaline synthesis was published in 1977 by David E. Nichols. Correlation between the effectiveness of hallucinogens in mouse head twitches and their behavioral and subjective effects in other species. [Sources: 1, 12, 15]

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[1]: https://www.psychedelicsdaily.com/drugs/proscaline/

[2]: https://hyperleap.com/topic/Proscaline

[3]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848748/

[4]: https://en.wikipedia.org/wiki/Proscaline

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[15]: https://en-academic.com/dic.nsf/enwiki/1501965

[16]: https://www.globalsources.com/si/AS/Dilligent-Pharmacy/6008854046821/pdtl/Proscaline-Mescaline-Meperidine/1178966894.htm

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