What Is JWH 018 Most Commonly Called?
What Is JWH 018 Most Commonly Called? Designer cannabinoids including JWH-018 (1-pentyl-3-(1-naphthoyl)indole) , AM-678, JWH-073, JWH-200, and (C8)-CP 47,497 were first discovered in ‘herbal smoking mixes,’ and are now offered under a variety of names, including K2, fake marijuana, Yucatan fire, skunk, moon rocks, and others.1-pentyl-3-(1-naphthoyl)indole was discovered as an ingredient in over 60 distinct ‘herbal’ products. 1-pentyl-3-(1-naphthoyl)indole – That ‘natural’ cannabinoid, widely used in conjunction with tobacco in the United States, primarily by vapers but also by electronic cigarette users, probably originated in a compound of the Brazilian Lourová Hyemeticus mold (vitressin) [it has never been found in any other substance]. This is a Class A drug and the legal classification is controlled as a Schedule 1 drug with an anesthetic-toxicological profile that raises the possibility of permanent brain damage if taken regularly for too long. Is this the origin of JWH-018?
What are some effects of JWH-018? | 1 Pentyl 3 1 naphthoylindole
It produces similar effects in animals to tetrahydrocannabinol (THC), a cannabinoid contained in cannabis, which has led in some countries to its use in synthetic cannabis products sold as incense or mixtures. [Sources: 6] The primary cannabinoid in cannabis, delta-9-tetrahydrocannabinol (D9-THC), is a partial CB1 receptor agonist. The analgesic effects of cannabinoid ligands are mediated by CB1 receptors, which are established well in the treatment of neuropathic pain, cancer pain, and arthritis.
1-pentyl-3-(1-naphthol)indole can produce psychoactive effects similar to those of THC when smoked. It is not psychoactive. Synthetic cannabinoids are synthetic cannabinoids designed to give the same psychoactive effects as THC but are not natural cannabinoids but are structurally very similar.
How is JWH-018 used?
When administered to mice, JWH 018 produces results consistent with those of other CB-1 receptor antagonists, including hypothermia, analgesia, decreased motor activity and catalepsy [5, 6]. It mimics the mechanisms by which THC in marijuana affects brain function and can lead to CNS depression. [Sources: 0, 10] Designer cannabinoids including 1-pentyl-3-(1-naphthoyl)indole, JWH-073, JWH-200, and (C8)-CP 47,497 were first discovered in ‘herbal smoking mixes,’ and are now offered under a variety of names, including K2, fake marijuana, Yucatan fire, skunk, moon rocks, and others. 1-pentyl-3-(1-naphthoyl)indole is one of the most commonly used cannabinoids, mostly in ‘bath salts and synthetic cannabinoid products like K2. 1-pentyl-3-(1-naphthoyl)indole is taken orally, injected, snorted, and inhaled. Can JWH-018 cause health effects? Warnings have been issued by both the U.S. Drug Enforcement Administration (DEA) and U.S. Food and Drug Administration (FDA) warning against ingestion, inhaling, or use with other drugs.
How addictive is JWH-018?1 | Pentyl 3 1 naphthoylindole
JWH-018 has been shown to be similar to morphine. The only way to accurately determine whether you are currently experiencing Naphthalen-1-yl-(1-pentylindol-3-yl)methanone intoxication is to be aware that this compound is under review by the FDA to determine the safety of this compound in all forms. 1-pentyl-3-(1-naphthoyl)indole is listed as one of the safest cannabinoids when smoked but is considered as high risk when ingested orally. This poses an added risk of potential addiction when someone uses it orally or taken in pill form, whether purchased or sold. What Are The Symptoms and Side Effects of JWH-018? Symptoms of 1-pentyl-3-(1-naphthoyl)indole include increased heart rate, increased sweating, sedation, and confusion. Despite the continuing misuse of synthetic cannabinoids in humans, little is known about the functional consequences of repeated administration of JWH 0.18 and related substances in spice products. Due to the possible negative side effects of this drug, it is possible to detect it as a synthetic drug by means of tests. [Sources: 0, 10]
Among the psychoactive substances found in Spice and K2 are the synthetic cannabinoids 1-pentyl-3-(1-naphthoyl)indole, JWH 0.73%, JWH 250, CP 47497, and C8. The accumulation of clinical evidence suggests that poisoning with spice or K2-like products can cause symptoms similar to the side effects of high doses of cannabis. For example, since March 2011 the authorities have information on five chemical compounds used in Spice that make it illegal: JWH, 0.83%, JWh 200, cannabicyclohexanol and CP 4749.7. [Sources: 3, 5, 8]
What are the risks of JWH-018 use?
What are the risks of JWH-018 use? Supplements are a growing trend in supplement sales. There are many reports concerning the negative effects of supplements. Naphthalen-1-yl-(1-pentylindol-3-yl)methanone can also be found in many ‘herbal’ products. Buy Now What is JWH-018? 1-pentyl-3-(1-naphthoyl)indole is a synthetic cannabinoid similar in structure to the natural cannabinoid THC.1-pentyl-3-(1-naphthoyl)indole is metabolized by the liver to THC. JWH-018 acts at much higher concentrations than THC, therefore, is much more potent. By reducing the amount of THC needed to get high, 1-pentyl-3-(1-naphthoyl)indole may produce more of a sedative effect.JWH-018 is an active ingredient in designer cannabinoids including JWH-018, JWH-073, JWH-200, and (C8)-CP 47,497.
What are the long-term effects of JWH-018 use?
Similar discriminatory stimulus effects of D9-THC were observed in mice treated with JWH 204, JWH 205, and 1-pentyl-3-(1-naphthoyl)indole (JWH 073) (Vann et al., 2009; Brent et al., 2013), and monkeys treated with JWH 0.18 and JWh 0.73 (Ginsburg et al., 2012 ). Analogous to D9-THC, doses of Jwh 018 mitigate withdrawal symptoms caused by rimonabant, a CB-1 receptor antagonist (G Ginsburg et al. ; 2012). [Sources: 3]
In a study published in 2011 severe toxicity after ingestion of synthetic cannabinoids was proposed for JWH 018, which led to seizures, tachyarrhythmia, and irregular heartbeat . In a 2010 review of clinical reports, addictions and withdrawal symptoms were associated with the use of synthetic cannabinoids, similar to those of cannabis abuse. As with chronic cannabis abuse, synthetic cannabinoids have been associated with several deaths, dangerous side effects, and toxicity in general. [Sources: 2, 4]
Although the side effects of cannabis are well documented , data on human toxicity associated with the use of synthetic cannabinoids are limited. As with other sold NPS products synthetic cannabinoids contain several chemicals in different concentrations, making it difficult to determine the substance-specific effects. The pharmacological and toxicological profiles of new and similar products are unknown, as are the content and unknown mechanisms underlying many of the side effects associated with the use of these substances (Brent et al., 2011). [Sources: 4, 7]
Typical side effects of synthetic cannabinoids are tachycardia, restlessness, nausea, and severe side effects such as seizures, acute kidney injuries, emerging psychosis, severe heart crises, and death (27, 42). The severity of side effects associated with synthetic cannabis use is generally higher than with marijuana (Brents et al., 2011). [Sources: 0, 7]
JWH-018 is found in a number of substances and is still the primary ingredient in many designer drugs, like the “cat poison” wasabi oil, synthetic THC, and synthetic marijuana. 1-pentyl-3-(1-naphthoyl)indole is also still sold in high-potency mixtures sold under names like “spice”, “mystery blend”, “sea breeze”, “day-u”, “dope”, “purple dragon”, “fish”, “sinilla”, “big snake”, “LA-VR-x”, “deep-fryer”, “party bong”, “day-u-3-tet”, “shock”, “fire-n-kiss”, “the hookah”, and “turbo boosters”. These products are often packaged in attractive and well-labeled packages, many containing small print not clearly delineating what is contained in the chemicals or in the quantities offered for sale